If screening hits are obtained from the Pathogen Box, the following evaluation is suggested to assess the initial quality of the hit:
Check whether the chemotype is known for the particular target/organism (there may be analogues in the Pathogen Box or the scientific literature).
Consult the cytotoxicity data to ensure the biological effect observed is not due to a general cytotoxicity.
Prioritize the hits based on any additional information about the drug-like properties. In vitro absorption, distribution, metabolism and excretion (ADME) data as well as in vivo pharmacokinetic experiments on the Pathogen Box compounds are currently on-going. MMV will report this data in due course in the supporting information of this website; meanwhile researchers are welcome to contact us regarding data availability.
Confirm activity from a fresh solid sample. MMV may be able to supply material for follow up screening , please contact us to discuss your requirements. If we cannot supply solid material we can provide information on any commercial suppliers or provide synthetic routes. Alternatively researchers can identify commercial suppliers using searchable websites including emolecules and Chemspider. Please note that MMV cannot guarantee compound availability and will not subsidize the purchase of the analogues.
MMV looks forward to hearing about your findings and will be happy to provide you with further assistance, where possible.