The Pathogen Box

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Catalysing neglected disease drug discovery

"Beta-set" composition selected for the Pathogen Box

Scientific selection committee has selected 635 chemotypes

17 June 2014

MMV and partners wish to thank everyone that sent in suggestions for the Pathogen Box.

The European Bioinformatics Institute’s open access database, (ChEMBL17) was analyzed and triaged to identify active chemotypes against the diseases of interest. In parallel partners from many disease areas were approached to share their expertise and contribute quality hit molecules or screening platforms. This effort has led to an initial list of 819 diverse chemotypes.

In June 2014, a Scientific Selection Committee composed of leading figures in medicinal chemistry reviewed the initial set of compounds to select 635 chemotypes termed as the “beta-set”.

These compounds are now being procured or synthesized for confirmatory screening.