The Pathogen Box

element-invisible
Catalysing neglected disease drug discovery

Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

26 October 2018

Clinton G. L. VealeĀ  andĀ  Heinrich C. Hoppe

MedChemComm

DOI: 10.1039/c8md00319j

Abstract

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

Read the full article on the Royal Society of Chemistry website.